1.
Angew Chem Int Ed Engl
; 60(17): 9412-9415, 2021 04 19.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33570831
RESUMO
We report a novel and general method to access a highly under-studied privileged scaffold-pyrimidines bearing a trifluoroborate at C4, and highlight the broad utility of these intermediates in a rich array of downstream functionalization reactions. This chemistry is underpinned by the unique features of the trifluoroborate group; its robustness provides an opportunity to carry out chemoselective reactions at other positions on the pyrimidine while providing a pathway for elaboration at the C-B bond when suitably activated.